2. Next, you and your colleagues attempt to isolate the gene coding for the defe

Question

2. Next, you and your colleagues attempt to isolate the gene coding for the defective enzyme. The gene sequence is shown in Table 29.2. You compare the sequence of the gene from your patient with three other patients you have had with the same symptoms. What is the amino acid change in the enzyme from your patient? What amino acid changes are associated with the enzymes from the other three patients? Justin Patient A Patient B Patient C Patient Base Pair LocationMutation 319 374 1004 1144 G?A G?C CT

Explanation / Answer

1) justin has mutation at 319 base ( G to A). but in gene sequence at position 319 base is C. codon is CGC. it codes for Arginine amino acid.

2) patient 1 has mutation at 374 base ( G to A). codon is GAC is now converted into AAC

GAC code for aspartic acid and AAC code for asparagine.

3) patient 2 has mutation at 1004 base ( G to C). codon is CGG is now CCG.

CGG code for Arginine amino acid and CCG code for proline amino acid

4)

patient 3 has mutation at 1144 base ( C to T). codon is CCT is now TCT.

CCT code for Proline amino acid and TCT code for Serine amino acid

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