You have a mouse strain that is predisposed to developing skin cancer. Based on

Question

You have a mouse strain that is predisposed to developing skin cancer. Based on the literature in the cancer field, you come up with a list of 10 potential candidate genes that might be mutated in these mice. You are convinced that the mice of this strain must harbor one of these mutations.

A. Design an experiment to determine which candidate gene from the list was actually mutated in this mouse. You may not use DNA sequencing.

B. When you do the experiment, do you need to take tissue samples from the tumor itself, or can you take tissue from anywhere in the mouse? Why?

Explanation / Answer

You have a mouse strain that is predisposed to developing skin cancer. Based on

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