Human papillomaviruses (HPVs) are a family of DNA viruses that cause genital war

Question

Human papillomaviruses (HPVs) are a family of DNA viruses that cause genital warts. HPVs have been predominantly associated with cervical cancer. One of the proteins encoded by the HPV virus is E5. E5 is a short transmembrane protein that forms a dimer or trimer.

A. E5 can form a stable complex with endogenous hot PDGF receptor. Explain how this could lead to cell transformation.

HPV also encodes protein E6 and E7. It has been shown that adding E6 and E7 to normal cells is a sufficient to transform them and induce uncontrolled mitosis. Initially, it was not clear how E6 and E7 accomplished this, but recently it has been demonstrated that E6 binds and inhibits p53, while E7 is known to bind and inhibit Rb.

B. Explain how these findings show how HPV causes warts (which are benign tumors).

C. How does HPV infection increases one's risk of developing cancer?

Explanation / Answer

Human papillomaviruses (HPVs) are a family of DNA viruses that cause genital war

Related Questions

Navigate

• Browse (All)
• Browse H
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.