3 A) Which of the following is FALSE regarding cyclin-CDK regulation? Two ubiqui

ID: 263928 • Letter: 3

Question

3 A) Which of the following is FALSE regarding cyclin-CDK regulation?

Two ubiquitin-protein ligases are responsible for the degradation of cyclins.

INK4 proteins directly bind to and block the activity of CDK4 and CDK6 in G1.

Many CKI proteins are proto-oncogenes.

CDK inhibitors are important for regulation of mammalian CDKs at each cell cycle stage.

3 B) Which of the following does NOT correctly match a cancerous mutation in a cell cycle gene with its mechanism of action?

Loss of p16 leads to premature Rb phosphorylation and premature cell cycle entry.

Overexpression of cyclin D promotes inappropriate, uncontrolled entry into the cell cycle.

Loss of Rb leads to premature transcription of mitotic cyclins and cell cycle progression.

Hyperactive E2F promotes transcription of mitotic cyclins, promoting progression through the cell cycle in the absence of the appropriate signals.

3 A) Which of the following is FALSE regarding cyclin-CDK regulation? Two ubiqui

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