Question 1: The germinal center is a region within the secondary B cell follicle

Question

Question 1: The germinal center is a region within the secondary B cell follicle where sustained B cell proliferation and differentiation take place. The processes of B cell proliferation and differentiation, including affinity maturation and class switching, require periodic interactions of the germinal center B cells with CD4 TFH cells. These periodic interactions between the B cells and TFH cells can occur:

E) When B cells up-regulate CXCR4 and migrate into the dark zone of the germinal center

Question 2: At early timepoints following an infection, examination of lymph node CD4 T cells responding to the pathogen would show a heterogeneous population of cells representing several different effector lineages. Likewise, the cytokines produced by these cells would include IFNgamma, IL-4, and possibly others. However, approximately one week later at the peak of the T cell response, the pathogen-specific CD4 T cell population would be largely homogeneous in their production of a single effector subset cytokine profile. This change comes about due to:

A) Increased proliferation of CD4 T cells making protective cytokines

A) When B cells migrate and form a primary focus of antibody-secreting plasmablasts in the medullary cords of the lymph node

Explanation / Answer

1st question : When b cells migrate to the border between B cell zone and R cell zone. ( B )

Second question : Death if the CD4+ T cells making the non protective cytokines . ( A )

Related Questions

Navigate

• Browse (All)
• Browse Q
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.