are its reactants and products? 2. The Citric Acid Cycle (50 pts) A) What specif

Question

are its reactants and products? 2. The Citric Acid Cycle (50 pts) A) What specific reactions could be considered to link (i) glycolysis to the citric acid cycle and (i) the citric acid cycle to oxidative phosphorylation? Describe THREE essential COFACTORS (NOT NAD+ and FAD) which are required for the successful oxidation of pyruvate to carbon dioxide. What are their roles? What do they contribute to the reactions in which they are involved? Which reactions of the citric acid cycle produce NADH? What are the names of the enzymes that catalyze these reactions? For what reason, other than NADH production, are these reactions of particular significance? B) C)

Explanation / Answer

A) Pyruvate to Acetyl CoA is entry point for Glycolysis to TCA cycle and succinate is entry point from TCA to oxidative phosphorylation.

CoA SH is cofactor involved in Pyruvate to carbon dioxide.

Pyruvate to Acetyl CoA catalysed by pyruvate dehydrogenase complex , Isocitrate to alpha ketoglutarate catalysed by Isocitrate dehydrogenase , Malate to oxaloacetate catalysed by Malate Dehydrogenase.

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