These are the all information have been given: a) What happens to a previously a

Question

These are the all information have been given:

a) What happens to a previously assembled actin filament that is placed in a test tube containing 0.5?M ATP-G-actin solution and is incubated there for one minute (you can assume that the solution contains an excess of ATP and Mg2+)?

b) The experiment in (a) is repeated, but this time with a starting concentration of 50nM actin filaments and 0.5?M ATP-G-actin (and excess of ATP and Mg2+). What happens to the actin filament?

c) The experiment in (a) is repeated again but this time a Cofilin molecule is included in the reaction. What happens to the actin filament?

d) How can blood platelets contain a 200?M concentration of unpolymerised G-actin?

Explanation / Answer

a) actin filament elongates with ATP hydrolysis

b) actin filaments elongates with ATP hydrolysis

c) actin filament depolymerization occurs

d) Thymosin, profilin and actin-depolymerizing factor (ADF) are the monomeric G-actin binding proteins. These are present in the platelets preventing actin polymerisation even in higher concentration of G-actin

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