Options for each choice are: 10,000 6,000 1,000 600 100 10 6 TEXT INCASE IMAGE F
ID: 261905 • Letter: O
Question
Options for each choice are:
10,000
6,000
1,000
600
100
10
6
TEXT INCASE IMAGE FAILS
Human fibroblasts (skin cells) do not normally express telomerase. After 60 cell divisions they become senescent. Fibroblasts in which telomerase has been turned on become immortal. Assuming an average telomere length of ~6000 bp at birth and a minumum functional telomere length of ~360 estimate the following parameters.
Options for each choice are:
10,000
6,000
1,000
600
100
10
6
AGGGTT repeats at birth Nucleotides lost per cell division AGGGTT repeats at senescence Nucleotides needed to be replaced per cell division to achieve immortality Human fibroblasts (skin cells) do not normally express telomerase. After 60 cell divisions they become senescent. Fibroblasts in which telomerase has been turned on become immortal. Assuming an average telomere length of A(?GC.in. ropes is ai: birth Nucleotides lost per cell division AGGGTT repeats at senescence Nucleotides needed to be replaced per cell division to achieve immortalityExplanation / Answer
Telomere length is approximately 6000 bp. The noncoding hexameric sequence AGGGTT has 6 base pairs.
Therefore, the number of AGGGTT repeats at birth would be 6000/6 = 1000
Approximately 100 nucleotides are lost during each cycle of replication.
Minimum functional telomere length is 360,
6000/360 is approximately 16.67 . therefore when the telomere length falls below 16, the cells will undergo senescence.
The AGGGTT repeats at senescence would be approximately 10.
The number of nucleotides needed to be replaced per cell division to achieve immortality would be 100.
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