Read the following abstract: \"MicroRNA-155 plays an important role in the infla

Question

Read the following abstract:

"MicroRNA-155 plays an important role in the inflammatory response macrophages, while present studies identified that miR-155 was up-expressed in gastritis induced by Helicobacter pylori. We found that miR-155 was over expressed in macrophages infected with H. pylori in vivo or in vitro. Subsequently, inflammatory cytokines IL-23, IL-10, TNF-? and IL-8 were increased significantly, and the expression of CD80, CD86 or COX2, NOS2. Were enhanced in H. pylori infection macrophages by regulated with miR-155mimics. Furthermore, the apoptosis of macrophages induced by H. pylori was increased obviously due to the over-expression of miR-155. Therefore, these observations indicated that miR-155 may act as a inflammatory promoter in H. pylori infected macrophages. These findings contribute us to understand the functions of miR-155 in gastritis induced by H. pylori furtherly"

Write an in depth question (Do not answer it) to the author of the abstract relating to the subject matter. The question must be open ended.

Explanation / Answer

From the abstract the most relevant question to the author would be :

What is the function/role of microRNA-155 in the inflammatory response of H. pylori infection macrophages in gastritis and their role in activation/apoptosis of macrophages that are infected by the bacteria?

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