What is loss of heterozygosity? a. Mutation of the wild-type allele in a heteroz

Question

What is loss of heterozygosity?

a. Mutation of the wild-type allele in a heterozygote whose other copy of the gene is already mutated.

b. The second mutation of a mutated allele in a heterozygote, which results in reversion to the normal phenotype.

c. The elimination of one of the alleles in a heterozygote.

d.The mutation of both alleles in a heterozygote.

2. How does the loss of heterozygosity contribute to the development of cancers?

a.Loss of heterozygosity of a tumor suppressor followed by mutation of a proto-oncogene can lead to cancer. b. Loss of heterozygosity of any gene can lead to cancer. c. Loss of heterozygosity of a proto-oncogene can lead to cancer. d. Loss of heterozygosity of no gene can lead to cancer.

Explanation / Answer

What is loss of heterozygosity?
The answer is c. The elimination of one of the alleles in a heterozygote.

2. How does the loss of heterozygosity contribute to the development of cancers?
The answer is a.Loss of heterozygosity of a tumor suppressor followed by mutation of a proto-oncogene can lead to cancer.

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