a normal women with albino father and no family history of hemophilia plans to h

Question

a normal women with albino father and no family history of hemophilia plans to have children with a hemophiliac man with normal skin pigmentation whose mother is albino. determine the probabilities of all possible phenotypes in their childre a normal women with albino father and no family history of hemophilia plans to have children with a hemophiliac man with normal skin pigmentation whose mother is albino. determine the probabilities of all possible phenotypes in their childre a normal women with albino father and no family history of hemophilia plans to have children with a hemophiliac man with normal skin pigmentation whose mother is albino. determine the probabilities of all possible phenotypes in their childre

Explanation / Answer

Let gene A control human pigmentation : A for normal and a for albino, normal is dominant and albino is recessive

Let gene H control haemophilia. Haemophilia is a sex linked recessive trait. It is therefore on the X chromosome

A normal woman with albino father and no family history of haemophilia.

Father is albino – aa, but daughter is normal, therefore she must have inherited the normal pigmentation A gene from her mother. No haemophilia has been recorded in the family

Therefore the genotype of the mother is AaXHXH

The man she marries is haemophilic with normal skin pigmentation with albino mother.

Albino mother - aaXHXh

The man has normal skin pigmentation therefore he has inherited ‘A’ from father.

Father – AA XHY

Therefore the man has genotype AaXhY

AXH

aXH

AXh

AAXHXh (normal skin non haemophilic)

AaXHXh (normal skin non haemophilic)

AY

AAXhY (normal skin haemophilic)

AaXHY (normal skin non haemophilic)

aXh

AaXHXh (normal skin non haemophilic)

aaXHXh (albino skin non haemophilic)

aY

AaXHY (normal skin non haemophilic)

aaXHY (normal skin non haemophilic)

AXH

aXH

AXh

AAXHXh (normal skin non haemophilic)

AaXHXh (normal skin non haemophilic)

AY

AAXhY (normal skin haemophilic)

AaXHY (normal skin non haemophilic)

aXh

AaXHXh (normal skin non haemophilic)

aaXHXh (albino skin non haemophilic)

aY

AaXHY (normal skin non haemophilic)

aaXHY (normal skin non haemophilic)

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