1. What causes synaptic facilitation? a. Buildup of Ca2 in the presynaptic termi
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Question
1. What causes synaptic facilitation? a. Buildup of Ca2 in the presynaptic terminal b. Release of greater than usual number of synaptic vesicles c. Release of synaptic vesicles loaded with extra neurotransmitter d. Activation of synaptotagmin 7 by means of phosphorylation e. Stronger binding of Ca to synaptotagmin 7 2. How is facilitation different from augmentation and potentiation? 3. Refer to the figure. 0.5 3 0.2 0.1 0 10 20 3040 50 Interval between stimuli (ms) At which time interval would the postsynaptic membrane potential of the second stimulus be greatest a. 8 ms b. 15 ms c. 20 ms d. 30 ms e. 50 msExplanation / Answer
1. Buildup of Ca2+ in presynaptic terminal
Synaptic facilitation is caused by the elevation in presynaptic Ca2+
2. augmentation (10sec) lasts longer than facilitation (1 sec)
Potentiation is more slowly developing than facilitation or augmentation, and decays more slowly (tdecay tens of seconds to minutes)
3. At 20 ms time interval will be the postsynaptic membrane potential of the second stimulus be greatest
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