(Janeway\'s immunology 9th ED QUESTION 6.8) Order the following events in the se

Question

(Janeway's immunology 9th ED QUESTION 6.8)

Order the following events in the sequence in which MHC class 2 processing happens in an antigen-presenting cell.

… The CD74 trimerization domain is cleaved

…. MHC class 2 is translocated into endoplasmic reticulum

…. Cathepsin S cleaves LIP22 and leaves the CLIP fragment in the MHC molecule

…… CD74 trimers bind noncovalently to MHC class 2 a:b heterodimers

…. HLA-DM catalyzes the release of CLIP and promotes peptide editing

….. MHC class 2 heterodimers are released from calnexin for transport to a low-pH endosomal compartment

Explanation / Answer

1. MHC class2 is translocated into endoplasmic reticulum.
2. CD74 triers bind noncovalently to MHC calss 2 a:b heterodimers
3. MHC class 2 heterodimers are released from calnexin for transport to a low-pH endosomal compartment
4. Cathepsin S cleaves LIP22 and leaves the CLIP fragment in the MHC molecule
5. HLA-DM catalyzes the release of CLIP and promotes peptide editing

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