Joe and his maternal aunt both are affected with a cytoplasmic (mitochondrial) t
ID: 259183 • Letter: J
Question
Joe and his maternal aunt both are affected with a cytoplasmic (mitochondrial) trait.Joe’s mother has passed away. Which of the following is WRONG?
Joe’s mother was affected
Joe’s maternal grandmother was affected
All of the aunt’s children will also show the trait.
Joe’s maternal uncle should be affected
All of Joe’s sibs should be affected
Joe’s maternal grandfather was affected
Which of the following statements about a pedigree would be most definitive in differentiating an AD from an XLD pattern of inheritance?
Affected males and females are seen in all generations.
An affected male has only one daughter, and that daughter is affected.
There are two instances where an uaffected parent has an affected parent and an affected child.
An affected father has a normal wife and an affected son.
A.Joe’s mother was affected
B.Joe’s maternal grandmother was affected
C.All of the aunt’s children will also show the trait.
D.Joe’s maternal uncle should be affected
E.All of Joe’s sibs should be affected
F.Joe’s maternal grandfather was affected
Explanation / Answer
Joe and his maternal aunt both are affected with a cytoplasmic (mitochondrial) trait.Joe’s mother has passed away. Which of the following is WRONG?
The answer are
All of the aunt’s children will also show the trait.
Joe’s maternal grandfather was affected
Becuase as it is an example for maternal inheritance (those are inherits through cytoplasm as female gamete only carries the cytoplasm) it inherits through mother only.
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