1. An occurrence of a gene made larger by trinucleotide repeats is: Allelic expa

Question

1. An occurrence of a gene made larger by trinucleotide repeats is:

Allelic expansion

Nucleotide expansion

Translocation mutation

Transformation

2. a chemical that can damage and/or change DNA is called a/an:

Allele

Endonuclease

Vector

Mutagen

3. An occurrence when a section of a chromosome relocates itself to an entirely different (non-homologous) chromosome is called a/an:

Inversion mutation

Translocation mutation

Transformation mutation

Duplication mutation

4. The tandem repeat in the sequence GGGAAGGGAAGGGAAGGGAAGGGAAG is:

GGA

GGGAA

GGAAG

GGAAGGG

A disease characterized by abnormally shaped hemoglobin is called:

Cystic Fibrosis

Sickle Cell Anemia

Marfan Syndrome

Leukemia

5. A point mutation that causes a substitution of a stop codon with an amino acid and leads to the formation of a longer protein is a:

Nonsense mutation

Missense mutation

Sense mutation

Frameshift mutation

6. Addition or deletion of nucleotides in a DNA sequence is known as a:

Nonsense mutation

Missense mutation

Sense mutation

Frameshift mutation

7. The least severe type of chromosomal mutation is:

Point

Frameshift

Inversion

Translocation

8. Chemicals inserting themselves into DNA can cause a:

Missense mutation

Nonsense mutation

Sense mutation

Frameshift mutation

9. A genetic condition caused by allelic expansion is:

Familial hypercholesterolemia

Fragile X syndrome

Alkaptonuria

Galactosemia

10. Which of the following is most likely the original DNA strand if the mutated DNA strand is ATAGUUGATGUA ?

ATAGAAGATGAA

ATAGCCGATGCA

ATAGGGGATGGA

ATAGTTGATGTA

11. An unbalanced chromosomal mutation would include a/an:

duplication (insertion)

inversion

translocation

denaturation

12. Many translocation mutations are found to be involved with:

cancers

sickle cell anemia

Huntington disease

cystic fibrosis

13. A common repeat throughout the human genome that is approximately 300 bases in length is called a/an:

EcoRI repeat

Hind repeat

Exo repeat

Alu repeat

14. A balanced chromosomal mutation includes:

imprintation

denaturation

inversion

deletion

Explanation / Answer

1.

Correct: an occurrence of the gene made larger by the nucleotide expansion is translocation mutation.

Hence the correct option is (2).

Incorrect: transformation is the method of passing genetic material whereas allelic expansion and mutation does not lead to trinucleotide repeats every time.

2.

A chemical that can damage or change the DNA is called as mutagen. Mutagen can lead to mutations in the DNA that can be harmful for the DNA structure.

Hence the correct option is (4).

Incorrect: endonuclease, alleles and vector are the part of DNA functioning.

3.

Correct: this is translocation mutation that lead to chromosome relocation to the different chromosome.

Hence the correct option is (2).

Incorrect: inversion mutation and duplication mutation occur in the same chromosome.

4.

Correct: tandem repeats occur in DNA when the pattern of one or more than one nucleotide is repeate and the repetition are directly adjacent to each other. So, in the given sequence this criteria has been justified by the sequence GGAAG.

Hence the correct option is (3).

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