2,4-Dinitrophenol (DNP) is a small molecule that renders membranes permeable to

Question

2,4-Dinitrophenol (DNP) is a small molecule that renders membranes permeable to protons. In the 1940s, small amounts were given to patients to induce weight loss. DNP was effective in melting away the pounds, especially promoting the loss of fat reserves. It is easy to overdose on, and die, so it is NOT a safe way to lose weight. a. Explain how it might cause weight loss. (4 pts) b. As an unpleasant side reaction, however, patients had an elevated temperature and sweated profusely during the treatment. Provide an explanation for these symptoms. (5 pts)

Explanation / Answer

a) DNP is used for weight loss program, DNP cause heat generation in our body cell, as a result they can not poduce energy effeciently. Within the body mitochondria is the main center for energy production. which produce energy with the help of ATP. Now, inside the cell, DNP inhibit the function of ATP. As a result mitochondrica can not produce energy efficiently. which result in increase in metabolism. When metabolism is increased it will results in weight loss.

b) When DNP increases the heat, it will produce toxic effecr on body, It can lead to problem in heart rate-such as irregular heart beat, breathing problem, execessive sweting.. When the metabolism rate is too high such as hyper metabolism, heat present in the body will produce fever and eventually respiratory failure.

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