The acetyl group of acetyl-CoA, produced by oxidative decarboxylation of pyruvat

Question

The acetyl group of acetyl-CoA, produced by oxidative decarboxylation of pyruvate in the mitochondrion, is transferred to the cytosol by the acetyl group shuttle. Similarly, the acyl group shuttle (the carnitine shuttle) transfers the fatty acyl group from the cytosol to the mitochondrion in preparation for ß oxidation. Select the statements that describe the similarities or differences between the acetyl group shuttle and the acyl group shuttle. Both the a group shuttle and the acetyl group shuttle keep the mitochondrial and the cytosolic pools of CoA separate. Both the fatty acyl group and the acetyl group cross the mitochondrial membrane after conjugation to another molecule The acyl group shuttle moves the fatty acyl group across the mitochondrial membrane by active transport, while the acetyl group shuttle is an antiport process. Although the acetyl group shuttle requires ATP, the acyl group shuttle is ATP-independent The acetyl-group shuttle generates NADPH, while the acyl group shuttle does not.

Explanation / Answer

Similarity -

Both the fatty acyl group and the acetyl group cross the mitochondrial membrane after conjugation to another molecule.

Difference-

The acetyl group shuttle generates NADPH , while the acyl group shuttle does not .

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