100 partial pressure of anygen 7. If curve 3 represents the binding of oxygen to

Question

100 partial pressure of anygen 7. If curve 3 represents the binding of oxygen to normal hemoglobin, which curve represents the binding of oxygen to hemoglobin at high altitudes in red blood cells with an increased concentration of BPG? A) Curve 1 Curve 2 Curve 3 D Curve 4 8. If curve 3 represents the binding of oxygen to normal hemoglobin, which curve represents the binding of oxygen to a mutant hemoglobin with multiple His>Gly mutations in the central cavity? A Curve 1 ) Curve 2 C) Curve 3 D) Curve 4 9. If curve 3 represents the binding of oxygen to normal hemoglobin, which curve represents the binding of oxygen to a mutant hemoglobin with surface Tyr- Phe and His>Arg mutations that abolish tetramer formation? A) Curve 1 B) Curve 2 C) Curve 3 Curve 4

Explanation / Answer

7) In the increase concentration of BPG at high altitude in red blood cells decrease the affinity state of hemoglobin and so the oxygen binding curve will shift to the right direction . Means ans is curve 4. Ans is D.

8) His - gly mutation increase the affinty of hemoglobin toward oxygen so increase cooperative behaviour. Therefore curve shift to left so the ans is curve 1.

9) tetramar formation is necessary for cooperative behaviour of hemoglobin. Defective tetramar due to mutation will lead to low affinity of hemoglobin toward oxygen and curve shift to right. So the ans is 4.

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