QUESTION 6 Which of the following is an example of step in a signaling pathway i

Question

QUESTION 6 Which of the following is an example of step in a signaling pathway in which phosphorylation leads to DOWNREGULATION of the signaling pathway? Oa Phosphorylation of receptor tyrosine kinase leads to recruitment of Grb2. Ob. Phosphorylation of G-protein coupled receptor by GRKs leads to recruitment of arrestin. OC Phosphorylation of CREB leads to increases in transcription. d-phosphorylation of MAPKK leads to MAPKK phosphorylation of MAPK. QUESTION 7 What would you anticipate to be true about a cellin which the phosphatase that targets (le that dephosphorylates) the GPCR? a. You would expect lower levels of internalization in this cell. Ob. You would expect lower levels of GPCR signaling in this cell. . You would expect the GPCR to be constitutively active. d. You would expect the pH levels of the endosome to be lower than in a wild-type cel.

Explanation / Answer

Option - (B)   Phosphorylation of G - protein coupled receptor by GRK'S leads to recruitment of arrestin. Arrestin functions to down regulate signal transduction by inactivating G - proteins.

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