Sickle cell disease (SCD) is found in numerous populations whose ancestral homes

Question

Sickle cell disease (SCD) is found in numerous populations whose ancestral homes are in the malaria belt of Africa and Asia. SCD is an autosomal recessive disorder that results from homozygosity for a mutant beta -globin gene allele. Data on one affected population indicates that approximately 17 in 100 newborn infants have SCD. What is the frequency of the wild-type (beta A) allele in this population? Express your answer using two decimal places. What is the frequency of the mutant (beta 8) allele in this population? Express your answer using two decimal places. What is the frequency of carriers of SCD in the population? Express your answer using two decimal places.

Explanation / Answer

Frequency of affected individual in the population =17/100---------means--------recessive homozygote

Recessive homozygote---------q^2= 17/100

hence frequency of Recessive allele q= 0.41-----------------mutant allele

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normal allele p=1-0.41=o.59-----------------normal allele

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carrier =2pq= 2 x o.59 x 0.41=0.4838

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