(2). Determine which of the 3 cytoskeletal elements is associated with each of t
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Question
(2). Determine which of the 3 cytoskeletal elements is associated with each of the following statements: (3 points) (a). Binds ATP (b). Binds GTP (c). Displays dynamic instability (d). Displays treadmilling (e). Found in microvilli (t). Found in cilia (g). Found in filopodia h). Connects to desmosomes (Gi). Supports the nuclear envelope G). Involved in muscle contraction (k). Involved in vesicle transport (1). Involved in separating chromosomes (3). Explain why the drug taxol, which stabilizes microtubules, is an effective treatment for cancer. (1 point) (4). Compare and contrast treadmilling and dynamic instability. Describe 3 ways they are similar and two ways they are different. (2 points)Explanation / Answer
2a- Microfilaments binds to ATP and are involved in the hydrolysis of the same
2b- Microtubules binds to GTP and are involved in the hydrolysis
2c- Microtubules are dynamically unstable.
2d- Microfilaments are known for the treadmill
2e- Microfilaments or actin filaments are found in microvilli
2f- Microtubules are found in cilia and flagella
2g- Microfilaments are found in filopodia
2h- Intermediate filaments connect desmosomes
2i- Intermediate filaments support the nuclear envelope by lining it from inside
2j- Microtubules are involved in muscle contractions
2k- Microtubules guide vesicle transport
2l- Microtubules separates chromosomes.
ans 3- taxol stabilize microtubule formation and thus protects microtubule disassembly. chromosomes are thus able to achieve a metaphasic spindle formation which prevents further cell division and triggers apoptosis in cells.
ans 4-
dynamic instability- the transition between growth and shrinkage phases; growing at one end constantly
treadmilling- constant length, net flux from - end to + end; allows microtubule movements; length is increasing at one end and decreasing from another end.
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