Suppose you have two A-B -type exotoxins, A-B and A \' -B \' . A-B binds specifi

Question

Suppose you have two A-B -type exotoxins, A-B and A'-B'. A-B binds specifically to neurons and prevents a neuron- specific function, which is essential for nerve pulse transmission. A'-B' binds specifically to kidney cells and stops protein synthesis.

A. What would a hybrid toxin, A'-B, do to kidney cells? Provide your rationale.

B. What would a hybrid toxin, A-B', do to kidney cells? Prodive your ratioale.

C. What would a hydrid toxin, A'-B, do to neurons? Provide your rationale.

D. What would a hybrid toxin A-B', do to neurons? Provide your rationale.

Explanation / Answer

The function of components of the endotoxins:

From the above information we can find the functions of the hybrids as follows:

Function of A'-B hybrid: binds specifically to neurons and stops protein synthesis

Function of A-B' hybrid: binds specifically to kidney cells and prevents a neuron- specific function

A. A'-B will not have any effect on kidney, as it does not bind with kidney cells.

B. A-B' will bind to kidney cells and prevents a neuron specific function, transmitting signals.

C. A'-B will bind to neuron and stops protein synthesis in neurons.

D. A-B' will not have any effect on neuron, as it does not bond to neurons.

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