optosis is a form of programmed cell death. It is a controlled process that is n

Question

optosis is a form of programmed cell death. It is a controlled process that is necessary throughout an organism's lifespan to maintain homeostasis. Apoptosis occurs through an extrinsic pathway and an intrinsic pathway. Complete the table by placing the labels in the correct box. Extrinsic Intrinsic How is the pathway initiated? What caspase initiates the proteolytic caspase cascade? What other proteins are involved in this pathway? Death ligand binds caspase-8 FADD Bcl-2 its receptor Change in the Bax/Bak levels caspase-9 DISC cytochrome c TNFa Please scroll down for more of this question. Apaf1 Consider the following cellular events that initiate apoptosis. Will apoptosis proceed through the extrinsic or

Explanation / Answer

Extrinsic Intrinsic

how is the pathway initiated death ligand binds its receptor change in Bak/Bax level

what caspase initiate the    caspase 8 caspase 9

proteolytic caspase cascade

what other proteins involved    FADD, DISC cytochrom-c, APaf-1, bcl2, TNFalpha

The webbing between feet is shed in a developing embryo- intrinsic pathway

A cell has undergone extensive DNA damage- extrinsic pathway

A cell has become higly deficient in nutrients- intrinsic pathway

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