1- What is the role of a rER translocon? a- Bind with a ribosome for peptide syn
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Question
1- What is the role of a rER translocon?
a- Bind with a ribosome for peptide synthesis in the rER lumen.
b- Flip proteins into the cytosol.
c- Bind a signal recognition particle.
d- Proofread newly assembled proteins.
e- Terminate translation.
2- Select all of the following categories of proteins which are made (synthesized by the Rough ER).
a- Secreted Proteins (like hormones, neutotransmitters)
b- Proteins integrated into a cell’s own plasma membrane
c-Proteins integrated into a cell’s own intracellular membranes (such as the Gogli, vesicles)
d-Proteins that are dissolved in a cell’s own cytosol
Explanation / Answer
1. What is the role of a rER translocon?
c- Bind a signal recognition particle.
Translocon is a protein complex that transports polypeptides with a target signal sequence into the interior space of ER from cytosol.
Retrotranslocon transports degraded proteins from ER into cytosol.
2. Select all of the following categories of proteins which are made (synthesized by the Rough ER).
a- Secreted Proteins (like hormones, neutotransmitters)
b- Proteins integrated into a cell’s own plasma membrane
c-Proteins integrated into a cell’s own intracellular membranes (such as the Gogli, vesicles)
Rough ER synthesizes transmembrane proteins and that remain in the membrane of final target organelle. The destined location for rER synthesised proteins include: Plasma membrane resident, Golgi resident, rER resident, Endosomes/lysosomes, extracellular space(secreted proteins).
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