NAME PCB3063C LECTURE ACTIVITY MARCH 28 6. In the table below, primary sequences
ID: 253590 • Letter: N
Question
NAME PCB3063C LECTURE ACTIVITY MARCH 28 6. In the table below, primary sequences of four different proteins are shown. Each mutant protein (Mutant 1 through 3) results from a separate and different mutation in the wild-type DNA sequence. Wild-type: Mutant 1: Mutant 2: Mutant 3: Met-Trp-Tyr-Arg-Gly-Ser-Pro-Thr Met-Trp Met-Trp-His-Arg-Gly-Ser-Pro-Thr Met-Cys-lle-Val-Val-Val-GIn-His Compare each mutant protein to the wild-type protein. Using the codon table, analyze all codons for amino acids in each protein. Predict the type of mutation that led to each amino acid change for each mutant protein.Explanation / Answer
For mutant 1, its a nonsense mutation leads to insertion of stop codon and truncated protein.
Mutant 2, missense mutation causes coding for different amino acid I.e., tyrosine (tyr) to histidine (his)
Mutant 3, frame shift, either due to deletion or insertion of single or multiple base (s) after start codon results coding of different/ newer amino acid sequence.
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