The major function of the hydrophobic sequence at the amino terminals of protein
ID: 253556 • Letter: T
Question
The major function of the hydrophobic sequence at the amino terminals of proteins that are to be ecreted from eukaryotic cells is to target those proteins to the rough ER a. True b. False 16. Polypeptides inside the ER are usually smaller than polypeptides synthesized from the same mRNA that have not entered the ER. a. True b. False 17. Plasma membrane transmembrane proteins are synthesized on the rough ER a. True b. False 18. A newly synthesized polypeptide chain enters the ER through a translocon 19. The initial site of N-linked glycosylation is the Golgi apparatus 20. Phospholipids are synthesized in the cytosolic halfof the ER membrane bilayer. 21. Smooth ER is abundant in cells active in steroid hormone synthesis 22. The Golgi apparatus is the main site of intracellular drug detoxification. a. True b. False a. True b. False a. True b. False a. True b. False a. True b. False 23. Synaptic vesicles use a special mode of fusion that is completely different from regulated secretion in a typical secretory cell. 24. Vesicle formation is driven by the binding of clathrin or COP proteins. 25. The main method by which a cell gets rid of old, worn-out organelles is exocytosis. a. True b. False a. True b. False a. True b. FalseExplanation / Answer
Answe 15 : a True
Explanation : Yes, all secretary proteins have the signal peptide sequence at amino terminals of proteins that target it to RER.
Answer 16: a True
Explanation : Yes, as the polypeptide chain transfered to ER the signal sequence immediately cleaved hence it is shorter than the polypeptide remain in cytoplasm.
Answer 17: a True
Explanation : Yes, all secreatry proteins and membrane proteins are synthesize at the surface of RER due to presence or signal peptide sequence.
Answer 18: a True
Explanation : Yes, all proteins are synthesize at the surface of RER are transported through translocon.
Answer 19: b False
Explanation : The initial N-linked glycosylation takes place in endoplasmic reticulum not in golgi body.
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