Question 1 While the SOS repair pathway can repair devastating pyrimidine dimers

Question

Question 1 While the SOS repair pathway can repair devastating pyrimidine dimers, it comes at a cost. Which of the following best explains the cost of repairing DNA via the SOS repair pathway? The other strand of DNA is used as a 1) template to repair the damaged strand of DNA. A nucleotide is removed so that DNA 2) polymerase IlI can move past the pyrimidine dimer. Sos will help DNA replication bypass 3 pyrimidine dimers but will do so by using random nucleotides in place of the lesion. The Sos repair pathway uses analogs in 4) place of nucleotides when repairing damaged DNA.

Explanation / Answer

1. SOS repair pathway instructs DNA polymerase III to insert any bases opposite the thymine dimers. This mechanism involves DNA polymerase III and two other gene products which are encoded by umuCD. This ables to bypass replication faster but leads to mutations. Hence, the correct answer is the 3rd option.

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