This week there are two article from the Alzheimer\'s Project. The goal of the p

Question

This week there are two article from the Alzheimer's Project.  The goal of the project was to show scientists conducting groundbreaking research and discoveries as well as reveal the debilitating disease close up.  As part of the project 15 supplemental films were developed to reveal the impact of the disease.  The first shares the story of the DeMoe family as they discuss their fight against early-onset Alzheimer (not a video).  The second family you will read about the impact of late-onset Alzheimer with the Nanney-Felts family. 

DeMoe Family: http://people.com/human-interest/wyoming-children-early-onset-alzheimer-s-disease/

Nanney-Felts Family:  http://www.nwtntoday.com/2009/04/21/hbo-to-feature-nanney-family-in-documentary/

After you have viewed each link, compare and contrast early-onset with late-onset Alzheimer's disease and discuss it's impact on the aging process.

Explanation / Answer

The increasing health burden of Alzheimer’s disease (AD), both social and economic is an international problem particularly in low and middle income countries. Despite AD mostly occurs in the elderly, a small proportion of AD occurred before the age of 65, which is called early onset AD (EOAD), and is considered to have a more aggressive course and shorter survival time. EOAD is also characterized by more severe perfusion and metabolic defects. EOAD has greater cognitive deterioration with time. there is more cortical atrophy, hypoperfusion and hypometabolism in EOAD than LOAD. The laboratory measures of C-reactive protein (CRP), creatinine and blood urea nitrogen (BUN) are usually higher in the LOAD population.

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