Second Position (S-end Mutations practice problem 1: The following is the DNA se

Question

Second Position (S-end Mutations practice problem 1: The following is the DNA sequence of the entire protein-coding region for some small gene in a eukaryote. Shown is the coding strand. The first row is the original sequence with no mutations. Subsequent rows represent a single mutation. Determine the molecular basis for each mutation (transition, transversion, frameshift insertion or frameshift deletion) and what effect there would be on the protein. coc CUA ACA GUU The original sequence of the coding strand of DNA is 5-TA ATGACTA ATGGCTGACAGCTTA A-3 Mutation A: 5'-TAATGA GTA A TGGCTGACAGCTTA A -3 Mutation B:5 T A A TGACT AATGG CTGGCAGCTTA A -3 Mutation C: 5 T A ATGACTAAATG GCTGA CAGCTTA A-3' Mutations practice problem 2: A mutation causing an addition or a deletion of one base pair resulted in the production of a nonfunctional mutant protein. The sequences of the normal and mutant proteins are given below. Normal: Met Ala-CysHisSer Mutant: Met AspVal ThrProAsn - Was this mutation cause by an insertion or a deletion? Below, list the codons in the coding sequence of the mRNA that is translated into the mutant protein. 2

Explanation / Answer

1- transition

2- transversion

3- frameshift insertion of A and deletion of G nucleotide

Note- transition occur when A changes to G or C to U while transversion occur when A changes to C Or u Nd G to C and U .

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