a. They account for nearly one third of all antibiotics administered b. They are

Question

a. They account for nearly one third of all antibiotics administered b. They are relatively broad spectrum drugs c. They are resistant to most penicillinases 23. Which of the following is NOT true about cephalosporins? generation has the widest range of antimicrobial properties and the least negative side effects 24. Drugs that act on DNA or RNA synthesis include b. Aminoglycosides c. Macrolides d. Monobactams 25. Drugs that act on protein synthesis include a. Chloramphenicol b. Sulfonamides c. Echinocandins 26. Streptomycin and gentamicin inhibit cells by inhibiting a. Cell wall synthesis b. Cell membrane formation c. Protein synthesis d. DNA replication 27. What group contains the first antimicrobic drugs? a. Macrolides b. Ketolides c. Sulfonamides d. Flucocytosine 28, Antimalaria drugs are . a. Quinines b. Synercid c. Trimethoprim d. Tetracycline 29. Which of the following would be more effective when targeting a gram negative bacteria, like E.coli? a. One that affects the cell wall b. One that affects synthesis of DNA c. One that affects the cell membrane d. Any of these will do Which of the following would be more effective when targeting a gram positive bacteria, like S. aureus? 30. a. b. c. d. One that affects the cell wall One that affects proteins One that affects the cell membrane Any of these will do

Explanation / Answer

1.D) As the first generation cephalosporins are of a narrow spectrum.

24. a) Fluoroquinolones function by inhibiting the activity of DNA gyrase and the topoisomerase IV enzymes.

25.a)Chloramphenicol which is a bacteriostatic and inhibits protein synthesis by binding to 50S subunit of the ribosome.It prevents the peptide bond from being formed.

26.c) They are protein synthesis inhibitors or aminoglycosides.

27.c) sulphonamides are broadly active group since 1940.

28.a) Quinines are antimalarial drugs.

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