Although ligand binding to 7TM receptors initiates a signal transduction pathway

Question

Although ligand binding to 7TM receptors initiates a signal transduction pathway by triggering a change in tertiary structure, another class of receptors involves dimerization upon ligand binding. The result of this is that:

A. intracellular protein kinase domains are brought together and activate one another by cross-phosphorylation.
B. intracellular domains acting as second messengers are proteolytically cleaved and free to move through the cytoplasm.
C. the intracellular domains are changed from a conformation having little organized structure into a highly organized structure.

Explanation / Answer

A. intracellular protein kinase domains are brought together and activate one another by cross-phosphorylation.

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