Pay particular attention to ways in which controlling enzyme activity affects th

Question

Pay particular attention to ways in which controlling enzyme activity affects this process

The biosynthesis of purines such as ATP and GTP is a multi-step enzyme pathway. Some of the steps of that pathway are depicted below.

Many of the enzymes in this pathway are allosterically regulated. Which of the following would you predict are true about the allosteric regulation of purine synthesis? (select two answers)

- Ribose 5-phosphate inhibits amidophosphoribosyl transferase.

-Ribose 5-phosphate inhibits ribose phosphate pyrokinase.

-ATP and GTP inhibit amidophosphoribosyl transferase.

- ATP and GTP activate ribose phosphate pyrokinase.

- PRPP activates amidophosphoribosyl transferase.

-PRPP activates ribose phosphate pyrokinase.

Ribose 5-phosphate Ribose phosphate pyrophosphokinase 5-phosphoribosyl pyrophosphate (PRPP) Amidophosphoribosy transferase 5-phosphoribosylamine Inosine monophosphate (IMP) ATP GTP Copyright The President and Fellows of Harvard College

Explanation / Answer

Correct answer d and f

ATP, GTP activate ribose pyrophosphate and pyrikinase

PRPP activate ribose pyrophosphate, pyrikinase

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