Some clinical situations require administration of a loading (initial) dose of a

Question

Some clinical situations require administration of a loading (initial) dose of a drug to establish a therapeutic plasma concentration without delay. This may be done giving a large initial dose orally but the intravenous (IV) route of administration is often required. Which of the following is a determinant of the initial plasma concentration of a drug given by rapid IV infusion? a. The first-order distribution rate constant b. The elimination clearance rate c. The central compartment volume of distribution d. The intercompartmental clearance rate

Explanation / Answer

Answer-b. The elimination clearance rate

The plasma concentration remains increasing until the drug gets eliminated from the body and balances the input.

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