1. Select the event that is essential for the transcription of the immunoglobuli

Question

1. Select the event that is essential for the transcription of the immunoglobulin heavy-chain gene. In the choices below, V is the variable region, C is the constant region, D is the diversity region, and J is the joining region of the heavy-chain gene.

A. The C and VJ regions are brought together by removal of exons by RNA splicing.
B. Somatic mutations in the V region alter the DNA sequence.
C. The leader sequence is cleaved off from the V region.
D. The promoter is brought closer to the enhancer by somatic rearrangements.
E. Imprecise recombination at the site of V(D)J fusion produces hypervariable regions.

2. Which description applies to post-translational gene regulation?

A. a gene cluster controlled by a single promoter that transcribes to a single mRNA strand
B. heritable changes in gene expression that occur without altering the DNA sequence
C. protein modifications such as addition of a functional group, or structural changes such as folding
D. mRNA modifications such as additions of a 5' cap and 3' poly-A tail and removal of introns
E. processing of exons in mRNA that results in a single gene coding for multiple proteins

Explanation / Answer

1.Option E where recombination occurs between a D region gene and J region gene etc.. that would result in a rearranged DNA. that is transcribed

2. option C would suit post ranslational gene regulation.Processing of unstable mRNA takes place just before translation, To give rise to stable proteins after translation

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