Place the sentences in their correct order and use the following words: 1, 2, T
ID: 226339 • Letter: P
Question
Place the sentences in their correct order and use the following words: 1, 2, T helper 1, granzymes, perforins, 17, CD8, inflammatory, phagocytic, APC, CD4
T-cell activation begins when an _______ delivers antigen to a CD4 or CD8 T cell.
In the case of a ____________ cell, it can differentiate into T helper ____________ cells which will activate ____________ cells.
Activated CD8 cells will mount a direct attack on target cells through the action of ____________ , which punch holes in membranes, and ____________ , which then enter through these passageways.
In contrast, ____________ T-cell activation requires the action of ____________ cells in order to differentiate into memory CD8 cells and activated CD8 cells.
It may also differentiate into a T helper ____________ cell for B-cell activation, or T helper ____________ or T regulatory cells for modulation of the ____________ response.
Explanation / Answer
Answer:
T-cell activation begins when an APC delivers antigen to a CD4 or CD8 T cell.
In the case of a CD4 cell, it can differentiate into T helper 1 cells which will activate phagocytic cells.
It may also differentiate into a T helper 2 cell for B-cell activation, or T helper 17 or T regulatory cells for modulation of the inflammatory response.
In contrast, CD8 T-cell activation requires the action of T helper 1 cells in order to differentiate into memory CD8 cells and activated CD8 cells.
Activated CD8 cells will mount a direct attack on target cells through the action of perforins, which punch holes in membranes, and granzymes, which then enter through these passageways
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