Use what you know about the bcl-2 family of genes (which includes the ced-9 gene
ID: 225777 • Letter: U
Question
Use what you know about the bcl-2 family of genes (which includes the ced-9 gene in C. elegans) to predict the outcomes of the situations described below.
Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Terms can be used once, more than once, or not at all.
prevent
overexpression
low
high
promote
lack of expression
1. In C. elegans, of ced-9 during embryonic development leads to the survival of cells that would normally undergo apoptosis.
2. In humans, cells that express levels of bcl-2 are more susceptible to apoptosis.
3. In humans, cells that express levels of bcl-2 are less likely to undergo apoptosis.
4. In human cells, of bcl-2 is associated with uncontrolled cell growth that leads to a type of cancer called follicular lymphoma.
5. In human cell lines, scientists can manipulate the cells to force the expression of bcl-2 to apoptosis.
6. In humans with follicular lymphoma, a potential therapeutic would be to the expression of bcl-2 in the cancerous cells.
prevent
overexpression
low
high
promote
lack of expression
1. In C. elegans, of ced-9 during embryonic development leads to the survival of cells that would normally undergo apoptosis.
2. In humans, cells that express levels of bcl-2 are more susceptible to apoptosis.
3. In humans, cells that express levels of bcl-2 are less likely to undergo apoptosis.
4. In human cells, of bcl-2 is associated with uncontrolled cell growth that leads to a type of cancer called follicular lymphoma.
5. In human cell lines, scientists can manipulate the cells to force the expression of bcl-2 to apoptosis.
6. In humans with follicular lymphoma, a potential therapeutic would be to the expression of bcl-2 in the cancerous cells.
Explanation / Answer
We know that bcl2 family of genes (humans) whose homologs in C.elegans is ced9 gene inhibits/represses apoptosis (programmed cell death).Hence,
1.OVEREXPRESSION
2.LOW
3.HIGH
4.LACK OF EXPRESSION
5.PROMOTE
6.PREVENT
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