Fill in the blank(s) in each statement below with the most appropriate term(s) f
ID: 223907 • Letter: F
Question
Fill in the blank(s) in each statement below with the most appropriate term(s) from the following list. Terms may be used more than once or not at all.
Dark zone
Light zone
Cortex
Centroblasts
Centrocytes
Follicular dendritic cells
Medullary cords
Memory B cells
Plasma cells
Isotype switch
TFH cells
Primary focus
1. Most centrocytes die by apoptosis in the ________________.
2. Initial activation of naïve B cells induced by thymus-dependent antigen occurs in the ___________ within ___________.
3. __________________ are rapidly dividing cells locate in the _______________ of the germinal centers.
4. __________________ expressing high affinity receptor interact with antigen captured by _________________ in the light zone.
5. Class switching occurs in the __________________ and requires direct contact between B cells and _____________.
6. Centrocytes expressing receptors specific for self antigen present in bone marrow are subjected to negative selection in the _________________.
7. Within lymph nodes, plasma cells are found primarily in the _______________ of secondary follicules.
8. Somatic hypermutation, which occurs in proliferating ________________ is critical for affinity maturation.
9. X-linked hyper-IgM syndrome results from a defect in CD-40 ligand on T cells, which affects B cells by blocking _________________.
10. Mature __________________ produce large amounts of soluble IgG.
Explanation / Answer
3) ________Mature B cells__ are rapidly dividing cells locate in the ____dark zone__ of the germinal centers
5)Class switching occurs in the __chromosome (DNA)_ and requires direct contact between B cells and antibody_.
7)Within lymph nodes, plasma cells are found primarily in the __medullary cords_ of secondary follicules
10)Mature _______B cells____ produce large amounts of soluble IgG.
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