A student is obsessed with immune responses to MCMV infection decides to study t
ID: 223832 • Letter: A
Question
A student is obsessed with immune responses to MCMV infection decides to study this subject for a master's thesis. She hypothesizes that there is helper (TH1) T cells in the mouse that team up with B cells to generate an antibody response to viral antigens. She asks you to help, and you took Immunology 471 together, so you give her advice. For her thesis, she plans on: Measuring a cytokine in the mouse blood that would be suggestive of an active TH1 response. This cytokine should be IL-_. What does this cytokine do? The mouse generates antibodies that bind and neutralize (deactivate) the MCMV virus. What should immunoglobulin of antibodies she expects to find in: The infected salivary gland? The infected mouse's blood?Explanation / Answer
Major cytokine produced in Th1 response is INTERFERON -GAMMA....
Immunological reactions mediated are macrophage activation and IgG production
Helps to kill intacellular microbes, chronic granulomatous diseases, inflammatory bowel disease, etc .
Antibodies produced in infected salivary glands are Ig-A variety as they are rich in lining epithelia and secretions of body
Antibodies in infected mouse blood are Ig-M if early onset,.Ig-G subtype after exposure...These are the neutralising antibodies
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