The membrane protein represented schematically below traffics along the secretor

Question

The membrane protein represented schematically below traffics along the secretory pathway from the endoplasmic reticulum to the Golgi apparatus and then to the plasma membrane The boxes represent membrane-spanning segments. A tyrosine residue in the polypeptide between membrane spanning segments 3 and 4 gets phosphorylated in the position indicated by the asterisk in the figure. Will this phosphorylated tyrosine be exposed to the extracelluar space or the cytosol? Explain your answer in three sentences or less. Predict which of the following mutations to ubiquitin regulatory proteins is likely to have the greatest effect on overall cellular proteostasis. Explain your answer in lessthanorequalto 3 sentences: Mutation to an E3 ligase that inhibits its normal function Mutation to an E2 ligase that inhibits its normal function Mutation to an E1 ligase that inhibits its normal function Mutation to an E2 ligase that increases its normal function Mutation to an E3 ligase that i

Explanation / Answer

D) phosphorylated tyrosine will be exposed to the cytosol because the newly formed protein is stored in the vesicles of Endoplasmic reticulum and are later transported .As endoplasmic reticulum is found in thecytosol the proteins are stored in them in ctosol

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