It is generally agreed that the position of the cleavage furrow is determined by
ID: 222245 • Letter: I
Question
It is generally agreed that the position of the cleavage furrow is determined by the anaphase mitotic spindle. Through what mechanism does the spindle appear to do this? The spindle causes the deactivation of RhoA in a narrow ring within the cortex. The spindle causes the activation of RhoA everywhere but in a narrow ring within the cortex. The spindle nucleates the polymerization of the actin filaments in the cleavage furrow. The spindle causes the activation of RhoA in a narrow ring within the cortex.Explanation / Answer
The spindle causes the activation of RhoA in a narrow ring with in the cortex.
During this process certain steps occurs:
1) anaphase spindle reorganisation
2) division plane specification
3) actin myocine ring assembly & contraction.
During the actin myocine ring assembly & contraction it leads to the formation of furrow. here at first the contractile rings comes in the middle of cel at the cortex then the RhoA protein regulates the pathway by promoting the assembly of actin myocine ring. RhoA stimulate neucliation of actin filament which leads to the geeration of new actin filament and its important for the contractile ring formation. Then RhoA promotes myocine2 activation by the Kinase Rock. the force for the contractile process is generated by the movement along the Actin Filament by the Myosine 2. Myosine2 uses the free energy released during hydrolysis of ATP to move along the Actin filament. Resulting the cell membrane to form the clevage furrow. Other proteins involves are Anillin & Septin.
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