What is a particular advantage of anti-angiogenesis therapy? Angiogenesis is wid

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What is a particular advantage of anti-angiogenesis therapy? Angiogenesis is widespread throughout the body, so drug delivery is simplified. The therapy targets genetically normal endothelial cells, which are less likely to generate drug-resistant variants than tumor cells are. Anti-angiogenesis drugs preferentially affect the mature, quiescent capillaries associated with tumors but not normal tissues. Single doses are typically sufficient to eliminate tumor vasculature. What is true of the Rip-Tag mouse model? Rip-Tag mice show tumors throughout the body by 10 weeks of age. Blood vessel density Increases before hyperplasic islets are visible. It expresses SV50 T antigens only in the Islets of Langerhans In the pancreas. Effectiveness of VECF expression in premalignant cells is prevented by the presence of insulin. Which of the following is true? At greater distances from capillaries, pH can drop to toxic levels. Liver and muscle tend to have low capillary densities. Hypoxia causes repression of the HIF l transcription factor, leading to repression of VEGF transcription. Lymphatic vessels have smaller diameters than capillaries.

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Answer 6: Choice 2 (Capillaries are internally lined by endothelial cells. Therapies which target anti-angiogenesis are primarily based upon the fact that destruction of these endothelial cells with genetic abnormalities and tendency to become tumorous will help in eradication of cancerous growth without affecting rest of the cells and developing drug resistance.)

Answer 7: Chioce 3 (the rip-tag mouse model is a recently developed mouse model of pancreatic cancer having much similarities to human models of pancreatic cancers. Specifically, this model shows differential VEGF and its receptor expression and primarily, they express the SV40 antigen which is modulated under the insulin promoter's transcriptional control. This model is very important to understand the mechanisms of disease progression and understanding the possible remedies.)

Answer 8: Choice 1 (when the distance of capillaries increases, there occurs increase in blood flow via these vessels due to decrease in cross-section area and hence, the oxygen diffusion rate decreases. This causes carbon dioxide to accumulate in the underlying tissue and thus causes decrease in pH due to acidification. This gradually causes local acidosis in the capillaries)

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