Question 2 2 points Save Answer In the following diagram showing five parallel s

Question

Question 2 2 points Save Answer In the following diagram showing five parallel signaling pathways downstream of a receptor tyrosine kinase (RTK) and a G-protein- coupled receptor (GPCR), indicate which boxes (A to E) correspond to the following proteins. Your answer would be a five-letter string composed of letters A to E only, e.g. CDBAE signal molecule GPCR RTK G protein G proteinphospholipase C Grb2 PI 3-kinase adenylyl cyclase diacylglycerol Ras MAP kinase kinase kinase MAP kinase kinase calmodulin PKA CaM-kinase MAP kinase Akt kinase () Cyclic AMP () Protein kinase C ) Sos () PI(3,4,5)P3 () Ca2+

Explanation / Answer

A) cyclic AMP , it is activated by adenylyl cyclase.

B) Ca +2 (IP3 opens calcium channnl in endoplasmic reticulum.

C) Protein kinase C ( DAG along with calcium in cytosol activate Protein KINASE C)

D) SOS ( SOS protein bind to Grb2 and activate RAS protein)

E) PI(3,4,5) P3, act as the docking site for the PKDI.

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