7. A prokaryotic gene 800 nucleotides in length is transcribed by bacterial RNA

Question

7. A prokaryotic gene 800 nucleotides in length is transcribed by bacterial RNA polymerase. Approximately how long will it take to transcribe this gene, assuming that bacterial RNA polymerase transcribes at 40 nucleotides/sec? 8. As opposed to the single RNA polymerase present in prokaryotes, eukaryotes have 3 different RNA polymerases, RNA Pol I, Pol II and Po I. If the processivity (speed at which they add nucleotides) are 45 nucleotides/sec, 60 nucleotides/sec and 55 nucleotides/sec respectively, how long would it take for yeast to transcribe a gene that is 1260 bp long? (Hint: Only RNA Pol II is responsible for mRNA synthesis.) 9. The three types of eukaryotic RNA polymerases can be distinguished on the basis of their sensitivity to a-amanitin, a highly toxic octapeptide. ? ama nitin is isolated from a common poisonous mushroom. Amanata halloides. A person poisoned ingestion of these mushrooms shows no immediate symptoms but liver function deteriorates over time due to lack of production of mRNAs necessary for protein synthesis. Which type of eukaryotic RNA polymerase is affected by a-amanitin? (Hint: Which eukaryotic RNA polymerase is involved in mRNA synthesis?) 10. Oncogenes aregenes which cause cancer when they are over-expressed. MYC is one such oncogene. Over expression of MYC has been associated with a number of cancers such as Burkitt's lympho ma, lung, breast and prostate cancer. The mRNA encoding MYC is 759 nucleotides long. How many amino acids are present in the MYC protein?

Explanation / Answer

7. After transcription is initiated, it will take about 20 seconds for RNA polymerase to transcribe the gene of length 800 nucleotides.

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