9. Soon after people are infected with HIV, they start to make antibodies agains

Question

9. Soon after people are infected with HIV, they start to make antibodies against the virus. Such individuals are said to have seroconverted. The graph below shows the percentage of HIV- fected individuals who remain AIDS-free as a function of time since seroconversion. Which of the ines in the figure (labeled a-c) is likely to represent indviduals who are heterozygous for all HLA loci? Justify your answer. (6 pts) 100 Percentage g of HIV- nfected 6 ndividuals who remain AIDS free 20 40- 0 4 8 12 162 Years since serocoversion

Explanation / Answer

Ans.

Line A- No HLA

Line B- Heterozygous for HLA

Line C- homozygous for HLA

Heterozygous means Having different alleles at a given locus on the pair of chromosomes present in the diploid state

In this figure line B show Survival analysis of the effect of all HLA combined indicated that the effects of HLA are codominant. Only patients who were heterozygous for HLA were considered, to exclude the strong influence of homozygosity on progression to AIDS.

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