-3033-24553-Cell &&Molecular; Biology OS0.24 80\' e Content Discussions Dropbox
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-3033-24553-Cell &&Molecular; Biology OS0.24 80' e Content Discussions Dropbox Quizzes Classlist Grades Edit Course My Home Calenda 00:00 Time Taken:1:06:50 Mallori Baker: Attempt 1 Question 14 (4 points) stions Which of the statements below IS NOT CORRECT about DNA repair mechanisms? a) DBS (double stranded break repair) may result in loss and or alteration (mutation) of b) NMR (mismatch repair) and BER (base excision repair) use a DNA homology c) a generic DNA repair mechanism involves a mismatch (or damage) recognition original DNA information matching system (MSH) to identify damaged DNA complex, a nuclease that removes the surrounding DNA, a DNA polymerase to reconstruct the damaged region and a DNA ligase to join the newly synthesized DNA strand with the existing d specific DNA repair mechanisms such as MMR (mismatch repair) and BER (base excision repair) differ in the way they recognize the damaged region, however both employ a nuclease to remove faulty DNA sequences, a DNA polymerase to fill the gap and a ligase to join DNA strands uestion 13 Saved 8Explanation / Answer
Ans 14. Among all the given options, b option seems to be the right answer, which is NOT CORRECT for the DNA repair mechanisms.
Abbreviation of mismatch repair is given wrong. It is actually MMR.
Base excision repair or BER works to recognize the Apurinic or Apyrimidinic sites (AP sites). That site is being recognised by the DNA glycosylases and broken by AP endonucleases. Later, the nicked DNA is acted upon by the DNA ploymerases and the DNA ligases.
Nucleotide excision repair removes a bulky segment of the DNA. Generally, pyrimidine dimers are removed through this repair. Here too, endonucleases remove a segment of DNA that is paired wrongly, later DNA polymerase act for the polymerisation of the DNA and ligase act for sealing the DNA.
Thus, BER and NER helps in repairing the apurininc/apyrimidinic sites and pyrimidine dimers respectively, however, the further action of enzymes is approximate common. But they don't recognise the DNA homology matching system to repair the DNA.
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