Paper Critique#2 Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defi
ID: 217762 • Letter: P
Question
Paper Critique#2 Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum dx.dol.org/10.1371/journalpbio 1001138 Due Wednesday, 28 March, by 5pm 1- Describe the most interesting finding of the paper, in your opinion, and explain why you found it interesting. (3 points, 4-5 sentences minimum) 2) Would IPP be able to rescue liver stage Plasmodium parasite viability in the presence of apicoplast destroying antibiotics? (2 points; 3-4 sentences minimum. 1pt. for trying and following instructions, 1 pt. for a correct answer)Explanation / Answer
1) I found the most interesting part is about apicoplast. Because it is the main target for anti-malarial. As it contains many different types of protein so if we get to know the role of all protein we can definitely find a good target for antimalarials. And the role of isoprenoid precursor biosynthesis is the only essential function of the apicoplast during blood-stage growth. Role of IPP is also important in apicoplasts as IPP supplementation also completely reverses death treatment with antibiotics that cause loss of the apicoplast.
2) yes. IPP able to rescue liver stage Plasmodium parasite viability in the presence of apicoplast destroying antibiotics.
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