1. If histones did not have a positive charge: A. there would be less attraction

Question

1. If histones did not have a positive charge:

A. there would be less attraction to DNA. B. they would bind to DNA more tightly. C. there would probably be no difference in DNA/histone interaction.

2.Encylopedia of DNA Elements (ENCODE) The objective of ENCODE is to:

A.Sequence the human genome B.Study bacterial DNA replication C.Assign a function to human

3.DNA sequences ENCODE has provided insight on:

A. Gene regulation B. Why different cells express DNA differently C. Regions of ‘noncoding’ DNA D. Areas of the genome associated with disease E. All of the above

Explanation / Answer

1. Histones are positively charged proteins (basic proteins) that bind with DNA which is a negatively charged. If histones don't have a positive charge there would be less attraction to DNA, it would repel instead of binding.

2. The ENCODE Project was the follow-up to the Human Genome Project. The Human Genome Project involved accurate sequencing of human genome; the ENCODE Project seeks to interpret this sequence.A goal of the ENCODE Project is to link variations in the expression of certain genes to the development of disease.The ENCODE Project has given researchers insight into how the human genome functions.

3. DNA sequence ENCODE has provided insight on area of the genome associated with the disease. These findings provide us new insights into the organization and regulation of genes and genome, and serve as an expansive resource for understanding human health and disease.

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