Which of the following statements regarding membrane proteins is FALSE? B) Perip

Question

Which of the following statements regarding membrane proteins is FALSE?

B) Peripheral membrane proteins position hydrophilic amino acid side chains in the loop portions of their secondary structure, but integral membrane proteins do not.

C) Amino acid side chains positioned on the outside surface of the transmembrane domain of integral membrane proteins are non-polar.

D) Amino acid side chains positioned inside the transmembrane domain (region) of integral membrane proteins may be polar or non-polar.

A) Integral membrane proteins use either -helical or ?-sheet secondary structure to satisfy the hydrogen-bonding requirements of backbone groups in portions of the protein that cross the bilayer.

Explanation / Answer

Answer:

(B) Peripheral membrane proteins position hydrophilic amino acid side chains in the loop portions of their secondary structure, but integral membrane proteins do not.

Explanation:

The hydrophobic regions of integral membrane proteins pass through the membrane and interact with the hydrophobic tails of the lipid molecules in the interior of the bilayer, where they are sequestered away from water. Their hydrophilic regions are exposed to water on either side of the membrane.

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