0 Figure12-40 Weinberg Cells lacking BRCA-2 (red line) are killed off(2 log k il
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0 Figure12-40 Weinberg Cells lacking BRCA-2 (red line) are killed off(2 log k ill or 99% kill) at 10E-7 M (0.1 uM) anti-PARP drug concentration (The structure of the inhibitor isnot specified). Cellswith BRCAblueor green lines can survive almost 1,000-fold higher concentration of anti-PARP agent (10E-4M or 100 uM) 2 BRCA2+ BRCA2 BRCA2 0 109 108 107 106 10 104 drug concentration (M) Figure 12- The Bielgyof Can to Garland Science 2007 (3 Pts Each) 1. What specific biochemical process is the anti-PARP drug inhibiting? 2. Why do the cells shown in the red line give such a different response to the anti-PARP drug? 3. What does "BRCA" stand for? 4. How could you further enhance the chemotherapeutic effects of the anti-PARP agent in patients? 5. We list ten different pathological effects that a growing cancer can have on a patient. List three of those: 1) 2) 3)Explanation / Answer
1. DNA repair.
2. This is because in the other two cases green an blue cells which were positive for BRCA because in these cells double stand breaks can still be repaired but in BRCA negative cells, these cells DNA double strand beaks cannot be repaired and the cells die with the inhibitor
3. BReast CAncer susceptibility gene
4. 1) Fatigue
2) weight loss
3) Pain and nausea
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