Suppose a person is homozygous for a mutation in the IRP gene that causes the IR

Question

Suppose a person is homozygous for a mutation in the IRP gene that causes the IRP protein to not bind iron, but can still bind to the IRE element. How would this mutation affect the amount of iron inside the cell and the health of the cell if there was high iron in the environment? xcess transferrin receptor will import excess iron, which will not cause toxicity. Excess transferrin receptor will import excess iron, which will cause toxicity. The low amount of transferrin receptor will stop importing iron, which will not cause toxicity. The low amount of transferrin receptor will stop importing iron, which will cause toxicity. #7 How would this mutation affect the regulation of the transferrin receptor mRNA? IRP remains bound to the mRNA even when iron is high, and translation of the mRNA is stopped when iron is high. IRP remains bound to the mRNA even when iron is high, and translation of the mRNA is continued even when iron is high. IRP would not bind to the mRNA even when iron is high, and translation of the mRNA is continued even when iron is high IRP would not bind to the mRNA even when iron is high, and translation of the mRNA is stopped when iron is high.

Explanation / Answer

1. B. Excess tranferrin receptor will import excess iron which will cause toxicity

2. A. IRP remains bound to the mRNA even when iron is high and translation of the mRNA is stopped when iron is high.

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